Nonviral Therapeutic Delivery
The Nonviral Therapeutic Delivery Committee is responsible for the development of ASGCT programming on several areas of focus. Gene therapies delivered by physical methods (electroporation, hydrodynamic delivery, ultrasound, laser) as well as newer delivery technologies such as exosomes are included. Novel RNA- and DNA-based expression vectors including transposons and integrases, minicircles, genome editors, and artificial chromosomes are a second focus. Innovative targeting methods for organ, cellular and intracellular nonviral therapeutic delivery are in the scope of the committee. Therapeutic application is emphasized using novel nonviral gene delivery methods and vectors for the treatment of genetic diseases and cancers. Finally, chimeric therapies combining viral, nonviral and cell-based methods are included.